Basic Information
ID: ALA5126053
Type: Binding
Description: Agonist activity at human P2X7R expressed in HEK293 cells assessed as reduction in YO-PRO-1 iodide dye uptake preincubated for 30 mins followed by YO-PRO-1 iodide addition and measured after 2 hrs by fluorescence based multimode plate reader analysis
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA5126053
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 526.61 | -0.56 | -0.56 |
| 521.21 | -1.17 | -1.17 |
| 521.21 | -0.97 | -0.97 |
| 507.18 | -1.63 | -1.63 |
| 548.20 | -0.69 | -0.69 |
| 509.17 | -0.65 | -0.65 |
| 506.20 | -1.66 | -1.66 |
| 524.23 | -0.92 | -0.92 |
| 597.31 | 0.40 | 0.40 |
| 508.17 | -1.92 | -1.92 |
| 563.29 | 0.00 | 0.00 |
| 715.40 | 2.10 | 2.10 |
| 815.52 | 4.41 | 4.41 |
| 775.45 | 2.12 | 2.12 |
| 531.20 | -0.96 | -0.96 |
| 583.28 | 0.53 | 0.53 |