Basic Information
ID: ALA5130015
Type: Binding
Description: Antagonist activity at human TLR9 expressed in HEK-blue hTLR9 cells assessed as inhibition of CpGB-induced NFkappaB activation preincubated with compound for 1 hrs followed by CpGB addition and measured next day by SEAP-based spectrophotometry assay
Organism: Homo sapiens
Cell type: HEK-Blue hTLR9
Activity Charts
Bioactivity
Activity Types for Assay ALA5130015
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 254.29 | 3.02 | 3.02 |
| 505.66 | 3.92 | 3.92 |
| 267.33 | 3.08 | 3.08 |
| 350.47 | 3.54 | 3.54 |
| 482.63 | 5.65 | 5.65 |
| 392.50 | 3.78 | 3.78 |
| 377.45 | 3.72 | 3.72 |
| 463.63 | 4.14 | 4.14 |
| 366.47 | 3.14 | 3.14 |
| 503.69 | 4.94 | 4.94 |
| 551.69 | 4.17 | 4.17 |
| 511.67 | 5.70 | 5.70 |
| 237.31 | 3.07 | 3.07 |
| 420.51 | 3.55 | 3.55 |
| 406.53 | 4.08 | 4.08 |
| 414.51 | 4.00 | 4.00 |
| 297.36 | 3.08 | 3.08 |
| 510.64 | 5.43 | 5.43 |
| 380.49 | 3.55 | 3.55 |
| 239.28 | 2.59 | 2.59 |
| 396.49 | 3.15 | 3.15 |
| 517.67 | 4.45 | 4.45 |
| 475.64 | 4.38 | 4.38 |
| 434.54 | 3.86 | 3.86 |
| 269.30 | 2.60 | 2.60 |
| 518.62 | 5.55 | 5.55 |
| 519.69 | 4.18 | 4.18 |
| 536.61 | 5.69 | 5.69 |
| 435.57 | 3.28 | 3.28 |
| 535.69 | 4.93 | 4.93 |
| 338.41 | 2.43 | 2.43 |
| 380.49 | 3.92 | 3.92 |
| 382.46 | 2.76 | 2.76 |
| 479.63 | 3.38 | 3.38 |
| 451.57 | 2.52 | 2.52 |
| 489.66 | 4.68 | 4.68 |
| 308.39 | 2.42 | 2.42 |
| 376.50 | 4.07 | 4.07 |
| 565.76 | 6.25 | 6.25 |
| 503.69 | 5.83 | 5.83 |