Basic Information
ID: ALA5130023
Type: Binding
Description: Antagonist activity at human TLR8 expressed in HEK-blue hTLR8 cells assessed as inhibition of CL075-induced NFkappaB activation at 20 uM preincubated with compound for 1 hrs followed by CL075 addition and measured next day by SEAP-based spectrophotometry assay
Organism: Homo sapiens
Cell type: HEK-Blue hTLR8
Activity Charts
Bioactivity
Activity Types for Assay ALA5130023
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 505.66 | 3.92 | 3.92 |
| 350.47 | 3.54 | 3.54 |
| 463.63 | 4.14 | 4.14 |
| 503.69 | 4.94 | 4.94 |
| 406.53 | 4.08 | 4.08 |
| 435.57 | 3.28 | 3.28 |
| 489.66 | 4.68 | 4.68 |
| 503.69 | 5.83 | 5.83 |