Basic Information
ID: ALA5133434
Type: Binding
Description: Inhibition of recombinant human topoisomerase 1 expressed in Saccharomyces cerevisiae RS190 assessed as relaxation of supercoiled plasmid pUC18 at 100 uM preincubated for 15 mins followed by substrate addition and measured after 1 min by GelRed staining based agarose gel electrophoresis method relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5133434
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 348.36 | 2.08 | 2.08 |
| 473.47 | 6.01 | 6.01 |
| 479.52 | 7.52 | 7.52 |
| 443.44 | 6.00 | 6.00 |
| 493.50 | 7.16 | 7.16 |
| 461.43 | 6.14 | 6.14 |
| 478.49 | 5.96 | 5.96 |
| 433.49 | 6.05 | 6.05 |
| 473.47 | 6.01 | 6.01 |
| 493.50 | 7.16 | 7.16 |
| 463.51 | 6.06 | 6.06 |
| 469.47 | 6.33 | 6.33 |
| 459.48 | 6.37 | 6.37 |
| 479.42 | 6.28 | 6.28 |
| 463.51 | 6.06 | 6.06 |
| 479.42 | 6.28 | 6.28 |
| 473.47 | 6.01 | 6.01 |
| 451.48 | 6.19 | 6.19 |
| 488.44 | 5.91 | 5.91 |
| 469.47 | 6.33 | 6.33 |
| 459.48 | 6.37 | 6.37 |
| 501.49 | 7.07 | 7.07 |
| 429.46 | 6.36 | 6.36 |
| 511.44 | 7.02 | 7.02 |
| 463.51 | 6.06 | 6.06 |
| 483.55 | 7.20 | 7.20 |
| 463.51 | 6.06 | 6.06 |
| 493.50 | 7.16 | 7.16 |
| 447.45 | 6.50 | 6.50 |
| 483.55 | 7.20 | 7.20 |
| 473.47 | 6.01 | 6.01 |
| 463.51 | 6.06 | 6.06 |
| 483.55 | 7.20 | 7.20 |
| 449.49 | 5.75 | 5.75 |
| 465.44 | 6.64 | 6.64 |
| 459.48 | 6.37 | 6.37 |