Basic Information
ID: ALA5135991
Type: Binding
Description: Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated with compound for 30 mins followed by R848 stimulation measured after 22 hrs by SEAP reporter assay
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA5135991
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 377.53 | 4.55 | 4.55 |
| 377.53 | 4.55 | 4.55 |
| 407.56 | 4.56 | 4.56 |
| 351.47 | 5.27 | 5.27 |
| 378.52 | 3.95 | 3.95 |
| 355.43 | 4.85 | 4.85 |
| 359.52 | 5.70 | 5.70 |
| 365.50 | 5.58 | 5.58 |
| 401.48 | 6.15 | 6.15 |
| 347.51 | 5.44 | 5.44 |
| 319.45 | 4.57 | 4.57 |
| 387.45 | 5.84 | 5.84 |
| 333.48 | 5.13 | 5.13 |
| 333.48 | 4.88 | 4.88 |
| 351.47 | 5.27 | 5.27 |
| 361.53 | 5.75 | 5.75 |
| 347.51 | 5.44 | 5.44 |
| 361.53 | 5.69 | 5.69 |
| 319.45 | 4.82 | 4.82 |
| 348.49 | 3.94 | 3.94 |
| 348.49 | 3.94 | 3.94 |
| 333.48 | 5.13 | 5.13 |
| 337.44 | 4.71 | 4.71 |
| 378.52 | 3.95 | 3.95 |
| 349.48 | 4.83 | 4.83 |
| 349.48 | 4.31 | 4.31 |
| 373.54 | 6.01 | 6.01 |
| 378.52 | 3.95 | 3.95 |
| 347.51 | 5.44 | 5.44 |
| 347.51 | 5.44 | 5.44 |
| 363.51 | 5.14 | 5.14 |
| 349.48 | 4.31 | 4.31 |
| 375.56 | 6.05 | 6.05 |