Basic Information
ID: ALA5136794
Type: Binding
Description: Inhibition of N-terminal His6-tagged USP8 (unknown origin) catalytic domain (734 to 1110 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as deubiquitinating activity using ubiquitin-rhodamine -110 as substrate incubated for 30 mins followed by substrate addition measured after 30 mins by ubiquitin-rhodamine-110 based fluorometric assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5136794
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 353.37 | 3.48 | 3.48 |
| 382.42 | 2.63 | 2.63 |
| 382.42 | 2.68 | 2.68 |
| 369.37 | 2.72 | 2.72 |
| 383.40 | 2.84 | 2.84 |
| 492.53 | 3.12 | 3.12 |
| 396.44 | 2.93 | 2.93 |
| 410.47 | 3.46 | 3.46 |
| 410.47 | 3.32 | 3.32 |
| 396.40 | 2.16 | 2.16 |
| 275.27 | 1.99 | 1.99 |
| 387.39 | 1.67 | 1.67 |
| 490.56 | 4.53 | 4.53 |
| 525.57 | 4.73 | 4.73 |
| 412.44 | 1.99 | 1.99 |
| 524.58 | 5.33 | 5.33 |
| 462.51 | 3.80 | 3.80 |
| 476.53 | 4.15 | 4.15 |
| 450.54 | 4.38 | 4.38 |
| 542.55 | 4.56 | 4.56 |