Basic Information
ID: ALA5138371
Type: Binding
Description: Inhibition of NLRP3 inflammasome activation in LPS-primed human THP-1 ASC knock out cells reconstituted with mouse ASC assessed as inhibition of IL-1beta release at 0.1 to 10 uM preincubated for 30 mins followed by nigericin stimulation and measured after 30 mins by ELISA
Format: BAO_0000219
Organism: Homo sapiens
Cell type: THP-1
Target: Interferon-inducible protein AIM2(ALA4630802)
Document: ALA5137000
Inhibition of NLRP3 inflammasome activation in LPS-primed human THP-1 ASC knock out cells reconstituted with mouse ASC assessed as inhibition of IL-1beta release at 0.1 to 10 uM preincubated for 30 mins followed by nigericin stimulation and measured after 30 mins by ELISA: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5138371
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 266.30 | 3.05 | 3.05 |