Basic Information
ID: ALA5138374
Type: Binding
Description: Inhibition of NLRP3 inflammasome activation in LPS/nigericin-stimulated PMA-differentiated human THP-1 macrophages assessed as reduction in pyroptosis pretreated with LPS followed by compound treatment for 30 mins then stimulation with nigericin and measured after 3 hrs by MTT assay
Organism: Homo sapiens
Cell type: THP-1
Activity Charts
Bioactivity
Activity Types for Assay ALA5138374
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 227.26 | 2.57 | 2.57 |
| 257.29 | 2.58 | 2.58 |
| 404.49 | 2.99 | 2.99 |
| 309.29 | 3.90 | 3.90 |
| 271.32 | 2.37 | 2.37 |
| 321.28 | 3.20 | 3.20 |
| 280.33 | 3.08 | 3.08 |
| 243.26 | 2.28 | 2.28 |
| 266.30 | 3.05 | 3.05 |
| 285.11 | ||
| 320.37 | 1.94 | 1.94 |
| 241.29 | 2.88 | 2.88 |
| 299.37 | 3.10 | 3.10 |
| 282.30 | 3.02 | 3.02 |
| 257.29 | 2.58 | 2.58 |
| 245.25 | 2.71 | 2.71 |
| 277.32 | 3.73 | 3.73 |
| 297.12 | ||
| 266.30 | 2.99 | 2.99 |
| 266.30 | 3.05 | 3.05 |
| 294.31 | 2.35 | 2.35 |
| 278.31 | 3.12 | 3.12 |
| 307.30 | 3.48 | 3.48 |
| 257.29 | 2.58 | 2.58 |
| 333.39 | 4.15 | 4.15 |
| 283.33 | 2.91 | 2.91 |
| 296.33 | 2.12 | 2.12 |
| 297.31 | 2.55 | 2.55 |
| 303.36 | 4.24 | 4.24 |
| 277.32 | 3.73 | 3.73 |
| 280.33 | 2.73 | 2.73 |
| 257.29 | 2.58 | 2.58 |
| 266.30 | 3.05 | 3.05 |
| 283.33 | 3.08 | 3.08 |
| 259.28 | 3.02 | 3.02 |
| 297.40 | 4.31 | 4.31 |
| 261.71 | 3.23 | 3.23 |
| 325.29 | 3.78 | 3.78 |
| 320.19 | 3.64 | 3.64 |
| 266.30 | 2.80 | 2.80 |
| 286.29 | 2.78 | 2.78 |
| 299.33 | 2.66 | 2.66 |
| 272.26 | 2.48 | 2.48 |
| 305.36 | 1.98 | 1.98 |
| 269.34 | 3.70 | 3.70 |
| 266.30 | 3.05 | 3.05 |
| 271.32 | 2.89 | 2.89 |
| 320.37 | 1.52 | 1.52 |
| 285.30 | 2.57 | 2.57 |
| 269.30 | 2.51 | 2.51 |
| 306.16 | 3.34 | 3.34 |
| 241.29 | 2.88 | 2.88 |
| 271.32 | 2.97 | 2.97 |
| 275.74 | 3.53 | 3.53 |
| 256.31 | 2.46 | 2.46 |
| 311.26 | 3.47 | 3.47 |
| 257.29 | 2.58 | 2.58 |
| 255.32 | 3.18 | 3.18 |
| 295.26 | 3.59 | 3.59 |
| 295.34 | 3.01 | 3.01 |
| 284.32 | 2.53 | 2.53 |
| 252.27 | 3.13 | 3.13 |
| 271.27 | 2.30 | 2.30 |
| 297.31 | 2.55 | 2.55 |
| 269.34 | 3.53 | 3.53 |
| 283.37 | 3.87 | 3.87 |
| 296.33 | 2.12 | 2.12 |
| 293.27 | 3.17 | 3.17 |