Basic Information
ID: ALA5138548
Type: Binding
Description: Inhibition of human C-terminal domain DNMT3b catalytic domain (568 to 853 residues) expressed in Escherichia coli BL21 (DE3) pLysS cells assessed as inhibition of methylated dI-dC formation using poly dI-dC and [Me-3H]SAM as substrate incubated for 45 mins in presence of DNMT3L by liquid scintillation counting analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5138548
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 384.42 | -1.44 | -1.44 |
| 478.64 | 5.18 | 5.18 |
| 402.47 | -0.72 | -0.72 |
| 505.49 | -3.40 | -3.40 |
| 550.60 | -1.48 | -1.48 |
| 634.65 | -3.20 | -3.20 |
| 606.60 | -3.89 | -3.89 |