Basic Information
ID: ALA5140066
Type: Binding
Description: Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by ATP addition and measured after 30 mins by ELISA
Organism: Mus musculus
Cell type: J774.A1
Activity Charts
Bioactivity
Activity Types for Assay ALA5140066
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 402.52 | 4.06 | 4.06 |
| 545.13 | 4.92 | 4.92 |
| 585.19 | 5.87 | 5.87 |
| 651.03 | ||
| 543.06 | 5.06 | 5.06 |
| 559.15 | 5.26 | 5.26 |
| 503.05 | 3.83 | 3.83 |
| 532.04 | 4.04 | 4.04 |
| 530.11 | 5.41 | 5.41 |
| 557.09 | 4.99 | 4.99 |
| 559.10 | 5.48 | 5.48 |
| 555.04 | 5.15 | 5.15 |
| 577.21 | 6.33 | 6.33 |
| 517.12 | 5.35 | 5.35 |
| 508.57 | 3.28 | 3.28 |
| 541.07 | 4.63 | 4.63 |
| 583.18 | 6.62 | 6.62 |
| 541.09 | 4.14 | 4.14 |
| 573.18 | 5.70 | 5.70 |
| 510.68 | 4.26 | 4.26 |
| 496.61 | 3.20 | 3.20 |
| 494.54 | 3.35 | 3.35 |
| 502.06 | 3.71 | 3.71 |
| 577.17 | 5.03 | 5.03 |
| 595.19 | 6.07 | 6.07 |
| 570.07 | 4.83 | 4.83 |
| 566.14 | 6.64 | 6.64 |
| 581.16 | 6.14 | 6.14 |
| 442.56 | 3.07 | 3.07 |