Basic Information
ID: ALA5144474
Type: Binding
Description: Competitive inhibition of human recombinant MGMT expressed in Escherichia coli STAR BL21 pRare cells assessed as cleavage of fluorescent labelled substrate by Bsp 119I at 12.5 uM using O6MeG-bearing substrate (S) incubated for 10 mins in presence of non-substrate CT-DNA followed by substrate addition and measured after 5 mins by coupled enzymatic analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5144474
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 540.03 | 6.46 | 6.46 |
| 554.05 | 6.24 | 6.24 |
| 657.13 | 4.64 | 4.64 |
| 583.05 | 5.00 | 5.00 |
| 653.19 | 6.95 | 6.95 |
| 463.93 | 3.96 | 3.96 |
| 610.16 | 7.80 | 7.80 |