Basic Information
ID: ALA5145445
Type: Binding
Description: Allosteric inhibition of recombinant human SHP2 PTP domain (237 to 535 residues) using DiFMUP as substrate preincubated for 30 mins and followed by substrate addition and measured by microplate reader method
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5145445
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 352.27 | 3.35 | 3.35 |
| 349.89 | 3.18 | 3.18 |
| 384.34 | 3.83 | 3.83 |
| 398.36 | 4.08 | 4.08 |
| 365.51 | 3.68 | 3.68 |
| 321.49 | 2.80 | 2.80 |
| 364.28 | 3.72 | 3.72 |
| 353.25 | 3.38 | 3.38 |
| 283.38 | 2.04 | 2.04 |
| 324.22 | 2.57 | 2.57 |
| 338.24 | 2.78 | 2.78 |
| 367.24 | 3.33 | 3.33 |
| 314.39 | 1.45 | 1.45 |
| 352.27 | 3.21 | 3.21 |
| 349.89 | 3.18 | 3.18 |
| 384.34 | 3.69 | 3.69 |
| 319.36 | 2.32 | 2.32 |
| 365.51 | 3.68 | 3.68 |
| 333.44 | 3.20 | 3.20 |
| 297.41 | 2.35 | 2.35 |
| 383.44 | 3.55 | 3.55 |
| 315.45 | 2.53 | 2.53 |
| 345.47 | 2.54 | 2.54 |
| 341.42 | 1.81 | 1.81 |
| 329.47 | 2.84 | 2.84 |
| 308.39 | 1.92 | 1.92 |
| 297.41 | 2.35 | 2.35 |
| 333.44 | 2.67 | 2.67 |
| 338.20 | 1.97 | 1.97 |
| 324.22 | 2.44 | 2.44 |
| 372.52 | 3.14 | 3.14 |
| 317.82 | 2.70 | 2.70 |
| 394.34 | 3.29 | 3.29 |
| 325.20 | 2.87 | 2.87 |
| 338.24 | 2.96 | 2.96 |
| 309.20 | 3.63 | 3.63 |
| 339.23 | 2.99 | 2.99 |
| 351.38 | 3.06 | 3.06 |
| 352.27 | 3.22 | 3.22 |
| 366.30 | 3.60 | 3.60 |
| 343.43 | 2.06 | 2.06 |
| 317.82 | 2.70 | 2.70 |
| 329.47 | 2.67 | 2.67 |
| 301.37 | 2.18 | 2.18 |
| 349.89 | 3.18 | 3.18 |
| 338.24 | 2.96 | 2.96 |
| 373.46 | 2.07 | 2.07 |
| 363.92 | 3.32 | 3.32 |
| 312.20 | 2.43 | 2.43 |