Basic Information
ID: ALA5145446
Type: Binding
Description: Allosteric inhibition of recombinant human SHP2 assessed as change in melting temperature by SYPRO orange dye based thermal shift assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5145446
Delta Tm
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 352.27 | 3.35 | 3.35 |
| 349.89 | 3.18 | 3.18 |
| 384.34 | 3.83 | 3.83 |
| 398.36 | 4.08 | 4.08 |
| 365.51 | 3.68 | 3.68 |
| 321.49 | 2.80 | 2.80 |
| 364.28 | 3.72 | 3.72 |
| 353.25 | 3.38 | 3.38 |
| 283.38 | 2.04 | 2.04 |
| 324.22 | 2.57 | 2.57 |
| 338.24 | 2.78 | 2.78 |
| 367.24 | 3.33 | 3.33 |
| 314.39 | 1.45 | 1.45 |
| 352.27 | 3.21 | 3.21 |
| 349.89 | 3.18 | 3.18 |
| 384.34 | 3.69 | 3.69 |
| 319.36 | 2.32 | 2.32 |
| 365.51 | 3.68 | 3.68 |
| 333.44 | 3.20 | 3.20 |
| 297.41 | 2.35 | 2.35 |
| 383.44 | 3.55 | 3.55 |
| 315.45 | 2.53 | 2.53 |
| 345.47 | 2.54 | 2.54 |
| 341.42 | 1.81 | 1.81 |
| 329.47 | 2.84 | 2.84 |
| 308.39 | 1.92 | 1.92 |
| 297.41 | 2.35 | 2.35 |
| 333.44 | 2.67 | 2.67 |
| 338.20 | 1.97 | 1.97 |
| 324.22 | 2.44 | 2.44 |
| 372.52 | 3.14 | 3.14 |
| 317.82 | 2.70 | 2.70 |
| 394.34 | 3.29 | 3.29 |
| 325.20 | 2.87 | 2.87 |
| 338.24 | 2.96 | 2.96 |
| 309.20 | 3.63 | 3.63 |
| 339.23 | 2.99 | 2.99 |
| 351.38 | 3.06 | 3.06 |
| 352.27 | 3.22 | 3.22 |
| 366.30 | 3.60 | 3.60 |
| 343.43 | 2.06 | 2.06 |
| 317.82 | 2.70 | 2.70 |
| 329.47 | 2.67 | 2.67 |
| 301.37 | 2.18 | 2.18 |
| 349.89 | 3.18 | 3.18 |
| 338.24 | 2.96 | 2.96 |
| 373.46 | 2.07 | 2.07 |
| 363.92 | 3.32 | 3.32 |
| 312.20 | 2.43 | 2.43 |