Basic Information
ID: ALA5149841
Type: Binding
Description: Inhibition of NLRP3 inflammasome in LPS-pretreated human THP1-ASC-GFP cells assessed as reduction in speck positive cells measured after 30 mins in presence of caspase inhibitor zVAD-FMK by Hoechst 33342 staining based confocal microscopy
Organism: Homo sapiens
Cell type: THP1-ASC-GFP
Activity Charts
Bioactivity
Activity Types for Assay ALA5149841
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 421.57 | 4.62 | 4.62 |
| 414.54 | 4.49 | 4.49 |
| 398.47 | 3.12 | 3.12 |
| 405.50 | 3.25 | 3.25 |