Basic Information
ID: ALA5151019
Type: Binding
Description: Inhibition of NAE (unknown origin) mediated neddylation assessed as decrease in NEDD8-Ubcl2 adduct formation incubated for 2 hrs in presence of L-glutathione and ATP by HTRF assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5151019
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 443.53 | 2.06 | 2.06 |
| 425.50 | 0.43 | 0.43 |
| 413.50 | 0.75 | 0.75 |
| 613.75 | 2.15 | 2.15 |
| 532.58 | -0.41 | -0.41 |
| 586.68 | 1.80 | 1.80 |
| 445.47 | 0.37 | 0.37 |
| 437.46 | 0.50 | 0.50 |
| 572.65 | 1.41 | 1.41 |
| 614.73 | 2.58 | 2.58 |
| 708.64 | 3.27 | 3.27 |
| 445.51 | 0.85 | 0.85 |
| 445.47 | 0.14 | 0.14 |
| 532.58 | -0.41 | -0.41 |
| 528.64 | 1.27 | 1.27 |
| 632.70 | 0.13 | 0.13 |
| 586.68 | 0.82 | 0.82 |
| 488.57 | 0.39 | 0.39 |
| 439.52 | 0.47 | 0.47 |
| 461.50 | -0.18 | -0.18 |
| 671.78 | 1.11 | 1.11 |
| 604.67 | 1.75 | 1.75 |
| 519.58 | 0.49 | 0.49 |
| 444.48 | 0.58 | 0.58 |
| 437.50 | 1.49 | 1.49 |
| 397.46 | 0.11 | 0.11 |
| 447.52 | 0.80 | 0.80 |
| 514.61 | 0.93 | 0.93 |
| 443.53 | 2.06 | 2.06 |
| 453.48 | -0.72 | -0.72 |
| 433.49 | 0.41 | 0.41 |
| 628.71 | 1.57 | 1.57 |
| 409.43 | -0.04 | -0.04 |
| 600.70 | 2.19 | 2.19 |