Basic Information
ID: ALA5151743
Type: Functional
Description: Antagonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as inhibition of LysoPalloT-NH-C3-ph-m-O-C11-induced AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay
Format: BAO_0000219
Organism: Mus musculus
Cell type: HEK293FT
Target: Probable G-protein coupled receptor 174(ALA3813587)
Document: ALA5149997
Antagonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as inhibition of LysoPalloT-NH-C3-ph-m-O-C11-induced AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5151743
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 573.66 | 5.25 | 5.25 |
| 616.69 | 4.12 | 4.12 |
| 574.65 | 3.81 | 3.81 |
| 616.69 | 4.38 | 4.38 |
| 616.69 | 4.12 | 4.12 |
| 644.74 | 4.76 | 4.76 |
| 602.66 | 3.73 | 3.73 |
| 616.69 | 4.12 | 4.12 |
| 559.64 | 4.86 | 4.86 |
| 558.65 | 4.28 | 4.28 |
| 670.78 | 5.29 | 5.29 |
| 616.69 | 3.82 | 3.82 |
| 586.66 | 4.76 | 4.76 |
| 630.72 | 4.51 | 4.51 |
| 559.64 | 4.86 | 4.86 |
| 544.58 | 3.44 | 3.44 |
| 644.74 | 4.90 | 4.90 |
| 664.73 | 5.02 | 5.02 |
| 616.69 | 4.12 | 4.12 |
| 678.76 | 5.33 | 5.33 |
| 616.69 | 4.12 | 4.12 |
| 720.84 | 6.32 | 6.32 |