Basic Information
ID: ALA5151840
Type: Binding
Description: Inhibition of human N-terminal His tagged MLL1(3745 to 3969)/WDR5 (22 to 334)/RbBP5 (1 to 538)/ASH2L (2 to 534)/DPY-30 (1 to 99) complex expressed in Escherichia coli assessed as decrease in methyltransferase activity preincubated with WRAD2 complex for 15 mins followed by substrate addition and measured after 1 hr using nucleosome peptide as substrate in presence of H3-SAM by scintillation counter analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5151840
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 575.57 | 3.22 | 3.22 |
| 511.00 | 4.62 | 4.62 |