ID: ALA5153174
Type: Binding
Description: Inhibition of NLRP3 inflammasome activation in LPS/ATP induced PMA-differentiated human THP-1 cells assessed as reduction in ASC expression in cell lysates at 20 to 40 uM pretreated for 24 hrs followed by LPS addition for 3 hrs and further incubated for 1 hr with ATP by Western blot analysis
Format: BAO_0000220
Organism: Homo sapiens
Cell type: THP-1
Subcellular Fraction: Lysates
Target: NACHT, LRR and PYD domains-containing protein 3(ALA1741208)
Document: ALA5150046
Inhibition of NLRP3 inflammasome activation in LPS/ATP induced PMA-differentiated human THP-1 cells assessed as reduction in ASC expression in cell lysates at 20 to 40 uM pretreated for 24 hrs followed by LPS addition for 3 hrs and further incubated for 1 hr with ATP by Western blot analysis: 1
Bioactivity
Activity Types for Assay ALA5153174
Inhibition
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
353.35 | 3.33 | 3.33 |