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Basic Information

ID: ALA5153174

Type: Binding

Description: Inhibition of NLRP3 inflammasome activation in LPS/ATP induced PMA-differentiated human THP-1 cells assessed as reduction in ASC expression in cell lysates at 20 to 40 uM pretreated for 24 hrs followed by LPS addition for 3 hrs and further incubated for 1 hr with ATP by Western blot analysis

Format: BAO_0000220

Organism: Homo sapiens

Cell type: THP-1

Subcellular Fraction: Lysates

Target:  NACHT, LRR and PYD domains-containing protein 3(ALA1741208)

Document:  ALA5150046

Inhibition of NLRP3 inflammasome activation in LPS/ATP induced PMA-differentiated human THP-1 cells assessed as reduction in ASC expression in cell lysates at 20 to 40 uM pretreated for 24 hrs followed by LPS addition for 3 hrs and further incubated for 1 hr with ATP by Western blot analysis: 1

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
353.353.333.33