Basic Information
ID: ALA5155265
Type: ADME
Description: Time dependent inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam as substrate preincubated for 30 mins in presence of NADPH by LC/MS/MS analysis relative to control
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Activity Charts
Bioactivity
Activity Types for Assay ALA5155265
TDI
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 412.50 | 3.86 | 3.86 |
| 427.51 | 3.44 | 3.44 |
| 481.48 | 4.15 | 4.15 |
| 565.58 | 2.78 | 2.78 |
| 553.65 | 1.60 | 1.60 |
| 456.55 | 3.50 | 3.50 |
| 473.54 | 1.66 | 1.66 |
| 635.67 | 3.07 | 3.07 |
| 446.51 | 2.63 | 2.63 |
| 484.48 | 3.64 | 3.64 |
| 508.60 | 2.42 | 2.42 |
| 430.51 | 2.93 | 2.93 |
| 537.52 | 2.15 | 2.15 |
| 416.49 | 2.54 | 2.54 |
| 446.51 | 2.17 | 2.17 |
| 487.61 | 3.04 | 3.04 |
| 390.45 | 2.15 | 2.15 |
| 520.62 | 2.56 | 2.56 |
| 551.55 | 2.54 | 2.54 |
| 444.54 | 3.32 | 3.32 |
| 488.59 | 3.07 | 3.07 |
| 563.56 | 2.54 | 2.54 |
| 460.54 | 2.29 | 2.29 |
| 534.64 | 2.95 | 2.95 |
| 509.59 | 1.53 | 1.53 |
| 458.57 | 3.75 | 3.75 |
| 500.48 | 3.52 | 3.52 |
| 450.93 | 3.28 | 3.28 |
| 572.59 | 4.05 | 4.05 |
| 502.62 | 3.46 | 3.46 |
| 484.48 | 3.48 | 3.48 |
| 474.57 | 2.68 | 2.68 |
| 482.49 | 3.23 | 3.23 |
| 502.62 | 3.46 | 3.46 |
| 494.58 | 2.03 | 2.03 |
| 470.54 | 3.03 | 3.03 |
| 526.54 | 2.83 | 2.83 |
| 455.52 | 3.44 | 3.44 |
| 460.54 | 2.56 | 2.56 |
| 509.59 | 2.00 | 2.00 |
| 516.60 | 3.41 | 3.41 |
| 474.57 | 2.54 | 2.54 |
| 544.53 | 3.13 | 3.13 |
| 522.63 | 2.81 | 2.81 |
| 581.70 | 2.53 | 2.53 |
| 448.53 | 2.15 | 2.15 |
| 554.60 | 3.76 | 3.76 |