Basic Information
ID: ALA5157449
Type: Toxicity
Description: Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells membrane vesicles assessed as inhibition of ATP-induced 14C-uric acid uptake preincubated for 15 mins followed by incubation with ATP and substrate for 5 mins by liquid scintillation counting analysis
Format: BAO_0000249
Organism: Homo sapiens
Cell type: HEK293
Subcellular Fraction: Membrane vesicle
Target: ATP-binding cassette sub-family G member 2(ALA5393)
Document: ALA5154691
Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells membrane vesicles assessed as inhibition of ATP-induced 14C-uric acid uptake preincubated for 15 mins followed by incubation with ATP and substrate for 5 mins by liquid scintillation counting analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5157449
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 370.41 | 4.73 | 4.73 |
| 386.41 | 4.86 | 4.86 |
| 477.52 | 5.87 | 5.87 |
| 433.47 | 5.84 | 5.84 |