Basic Information
ID: ALA5158481
Type: Binding
Description: Inhibition of 6-His tagged-G4SG4 fused ZIKV NS2B (49 to 95 residues) R95A mutant-NS3 (1 to 170 residue) R29G mutant expressed in Escherichia coli BL21 (DE3) using Bz-Nle-K-RR-AMC substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay
Organism: Zika virus
Activity Charts
Bioactivity
Activity Types for Assay ALA5158481
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 548.69 | -0.71 | -0.71 |
| 718.80 | 2.66 | 2.66 |
| 524.67 | 0.80 | 0.80 |
| 533.68 | -1.70 | -1.70 |
| 712.81 | 3.66 | 3.66 |
| 643.88 | 0.90 | 0.90 |
| 630.79 | 2.34 | 2.34 |
| 548.69 | -1.91 | -1.91 |
| 561.73 | -0.92 | -0.92 |
| 814.95 | 5.20 | 5.20 |
| 802.94 | 5.57 | 5.57 |
| 788.91 | 5.23 | 5.23 |
| 575.76 | -0.71 | -0.71 |
| 620.84 | 3.01 | 3.01 |
| 794.96 | 5.96 | 5.96 |
| 625.78 | -0.86 | -0.86 |
| 574.71 | 0.07 | 0.07 |
| 712.81 | 4.01 | 4.01 |
| 857.80 | 6.54 | 6.54 |
| 576.70 | -1.99 | -1.99 |
| 726.80 | 2.53 | 2.53 |
| 671.87 | 0.93 | 0.93 |
| 554.72 | -1.85 | -1.85 |
| 774.89 | 5.30 | 5.30 |
| 718.80 | 2.66 | 2.66 |
| 565.70 | -0.84 | -0.84 |
| 789.90 | 5.69 | 5.69 |
| 638.82 | -0.08 | -0.08 |
| 588.74 | 0.47 | 0.47 |
| 651.86 | 0.56 | 0.56 |
| 712.81 | 4.01 | 4.01 |
| 595.75 | -0.74 | -0.74 |
| 566.71 | -0.20 | -0.20 |
| 614.79 | 2.63 | 2.63 |
| 608.74 | 0.14 | 0.14 |
| 524.67 | 0.80 | 0.80 |
| 789.90 | 4.62 | 4.62 |
| 795.95 | 4.03 | 4.03 |
| 857.80 | 6.54 | 6.54 |
| 595.75 | -0.74 | -0.74 |
| 694.93 | 0.58 | 0.58 |
| 676.84 | 2.13 | 2.13 |
| 774.89 | 5.55 | 5.55 |
| 780.91 | 5.36 | 5.36 |
| 683.68 | 3.94 | 3.94 |
| 616.60 | 0.00 | 0.00 |
| 625.78 | -0.86 | -0.86 |
| 637.83 | 0.52 | 0.52 |
| 561.73 | -0.92 | -0.92 |
| 794.96 | 5.61 | 5.61 |
| 789.90 | 4.62 | 4.62 |
| 788.91 | 5.23 | 5.23 |
| 658.89 | -0.34 | -0.34 |
| 651.86 | 0.86 | 0.86 |
| 548.69 | -1.91 | -1.91 |
| 823.36 | 5.88 | 5.88 |
| 573.74 | -0.82 | -0.82 |
| 808.93 | 4.50 | 4.50 |
| 623.80 | 0.36 | 0.36 |
| 689.81 | 4.20 | 4.20 |
| 673.84 | -0.22 | -0.22 |
| 718.80 | 2.66 | 2.66 |
| 519.65 | -2.09 | -2.09 |
| 675.78 | 3.64 | 3.64 |
| 581.72 | -0.61 | -0.61 |
| 560.68 | -0.23 | -0.23 |
| 609.73 | -1.10 | -1.10 |
| 818.94 | 5.24 | 5.24 |
| 690.83 | 1.52 | 1.52 |
| 779.86 | 4.22 | 4.22 |
| 573.74 | -1.05 | -1.05 |
| 664.83 | 1.69 | 1.69 |
| 790.88 | 5.66 | 5.66 |
| 631.80 | 0.01 | 0.01 |
| 788.91 | 5.23 | 5.23 |
| 638.82 | -0.08 | -0.08 |
| 818.94 | 5.24 | 5.24 |
| 718.80 | 2.66 | 2.66 |
| 808.93 | 4.50 | 4.50 |
| 824.97 | 4.99 | 4.99 |
| 788.91 | 5.23 | 5.23 |
| 576.75 | -0.83 | -0.83 |
| 553.73 | -1.25 | -1.25 |
| 675.82 | 1.52 | 1.52 |
| 591.76 | -1.69 | -1.69 |
| 547.71 | -1.31 | -1.31 |
| 802.94 | 5.27 | 5.27 |
| 698.74 | 1.82 | 1.82 |
| 614.79 | 2.63 | 2.63 |
| 471.61 | -2.53 | -2.53 |
| 832.92 | 4.96 | 4.96 |
| 656.85 | 2.03 | 2.03 |
| 650.81 | 1.65 | 1.65 |
| 651.79 | 1.04 | 1.04 |
| 698.79 | 3.40 | 3.40 |
| 641.76 | 0.63 | 0.63 |
| 688.78 | 2.75 | 2.75 |