Basic Information
ID: ALA5160512
Type: Binding
Description: Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubated with compound for 15 mins followed by incubation with IFNgamma/LPS for 18 hrs by LC/MS/MS analysis
Format: BAO_0000221
Organism: Homo sapiens
Tissue: Blood
Target: Indoleamine 2,3-dioxygenase(ALA4685)
Document: ALA5154775
Inhibition of IDO1 in IFNgamma/LPS stimulated human whole blood assessed as unbound concentration using kynurenine/tryptophan as substrate preincubated with compound for 15 mins followed by incubation with IFNgamma/LPS for 18 hrs by LC/MS/MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5160512
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 370.88 | 4.54 | 4.54 |
| 424.86 | 4.64 | 4.64 |
| 480.41 | 5.70 | 5.70 |
| 388.44 | 4.67 | 4.67 |
| 474.45 | 5.04 | 5.04 |
| 446.40 | 4.31 | 4.31 |
| 444.43 | 5.46 | 5.46 |
| 402.47 | 4.98 | 4.98 |