Basic Information
ID: ALA5160706
Type: Binding
Description: Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity at 5 uM by measuring adriamycin IC50 after 48 hrs by MTT assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: K562/A02
Target: P-glycoprotein 1(ALA4302)
Document: ALA5154779
Reversal of P-gp-mediated multidrug resistance in human K562/A02 cells assessed as potentiation of adriamycin-induced cytotoxicity at 5 uM by measuring adriamycin IC50 after 48 hrs by MTT assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5160706
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.61 | 5.09 | 5.09 |
| 446.91 | 4.28 | 4.28 |
| 646.74 | 6.37 | 6.37 |
| 469.58 | 3.64 | 3.64 |
| 414.85 | 3.84 | 3.84 |
| 463.92 | 4.03 | 4.03 |
| 419.87 | 3.98 | 3.98 |
| 426.90 | 2.49 | 2.49 |
| 412.88 | 2.10 | 2.10 |
| 479.92 | 3.99 | 3.99 |
| 390.83 | 3.36 | 3.36 |
| 390.83 | 3.36 | 3.36 |
| 460.92 | 4.13 | 4.13 |
| 488.98 | 4.17 | 4.17 |
| 438.31 | 4.67 | 4.67 |
| 415.84 | 4.17 | 4.17 |
| 465.94 | 5.64 | 5.64 |
| 473.96 | 4.04 | 4.04 |
| 479.97 | 5.88 | 5.88 |
| 535.05 | 5.89 | 5.89 |
| 403.87 | 4.01 | 4.01 |
| 473.84 | 4.87 | 4.87 |
| 421.86 | 4.15 | 4.15 |
| 465.94 | 5.56 | 5.56 |