Basic Information
ID: ALA5160877
Type: Binding
Description: Protac activity at VHL/EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as induction of EGFR degradation at 100 nM incubated for 24 hrs by Western blot analysis relative to control
Format: BAO_0000219
Organism: Homo sapiens
Cell type: NCI-H1975
Target: VHL/EGFR(ALA4523998)
Document: ALA5154782
Protac activity at VHL/EGFR L858R/T790M mutant in human NCI-H1975 cells assessed as induction of EGFR degradation at 100 nM incubated for 24 hrs by Western blot analysis relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5160877
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 1097.44 | ||
| 1026.32 | ||
| 1121.43 | ||
| 1078.40 | ||
| 1125.50 | ||
| 537.67 | 4.41 | 4.41 |
| 1171.48 | ||
| 1139.40 | ||
| 1107.40 | ||
| 1050.35 | ||
| 1026.32 | ||
| 1154.50 | ||
| 1150.46 | ||
| 1092.43 | ||
| 1168.52 | ||
| 1153.51 | ||
| 1064.37 |