Basic Information
ID: ALA5161768
Type: Functional
Description: Inhibition of MAT2A in human HCT116-MTAP null cells xenografted in nu/nu mouse model assessed as reduction in brain SAM level by measuring EACU50 (0 to 12 hrs) at 0.3 to 10 mg/kg, po administered 2 times QD or 0.3 to 3 mg/kg, po administered 3 times BID and measured upto 24 hrs post last dose
Organism: Mus musculus
Activity Charts
Bioactivity
Activity Types for Assay ALA5161768
EAUC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 430.89 | 4.99 | 4.99 |