Basic Information
ID: ALA5162371
Type: ADME
Description: Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate at 10 uM preincubated for 5 mins followed by NADPH addition and measured after 45 mins by LC-MS/MS analysis
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Target: Cytochrome P450 2D6(ALA289)
Document: ALA5154811
Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate at 10 uM preincubated for 5 mins followed by NADPH addition and measured after 45 mins by LC-MS/MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5162371
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 565.64 | 4.90 | 4.90 |
| 536.60 | 4.81 | 4.81 |