Basic Information
ID: ALA5162488
Type: ADME
Description: Inhibition of CYP3A4 in human liver microsomes using midazolam as a substrate preincubated for 10 mins followed by NADPH addition and measured after 20 mins by LC/MS/MS analysis
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Activity Charts
Bioactivity
Activity Types for Assay ALA5162488
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 358.40 | 2.48 | 2.48 |
| 414.51 | 3.74 | 3.74 |
| 372.43 | 2.72 | 2.72 |
| 448.53 | 3.94 | 3.94 |