Basic Information
ID: ALA5163247
Type: ADME
Description: Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate incubated for 10 mins in presence of NADPH by LC-MS/MS analysis
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Target: Cytochrome P450 2D6(ALA289)
Document: ALA5154826
Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate incubated for 10 mins in presence of NADPH by LC-MS/MS analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5163247
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 369.41 | 2.40 | 2.40 |
| 376.40 | 3.18 | 3.18 |
| 378.41 | 3.56 | 3.56 |
| 377.42 | 4.17 | 4.17 |
| 344.38 | 2.73 | 2.73 |
| 349.37 | 3.55 | 3.55 |
| 390.42 | 3.49 | 3.49 |
| 376.40 | 3.18 | 3.18 |
| 363.40 | 3.86 | 3.86 |
| 362.37 | 2.87 | 2.87 |
| 344.38 | 2.73 | 2.73 |