Basic Information
ID: ALA5164911
Type: Binding
Description: Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse J774.A1 cells assessed as reduction in pyroptosis at 10 uM pretreated for 4 hrs with LPS and for 30 mins with compound prior to ATP addition and measured after 30 mins by PI/Hoechst33342 staining based analysis
Organism: Mus musculus
Cell type: J774.A1
Activity Charts
Bioactivity
Activity Types for Assay ALA5164911
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 193.16 | 1.66 | 1.66 |
| 364.44 | 0.38 | 0.38 |
| 458.51 | 5.94 | 5.94 |
| 456.50 | 5.77 | 5.77 |
| 444.49 | 5.68 | 5.68 |
| 464.91 | 6.03 | 6.03 |
| 448.45 | 5.51 | 5.51 |
| 410.47 | 5.11 | 5.11 |
| 434.45 | 5.28 | 5.28 |
| 464.91 | 6.03 | 6.03 |
| 509.36 | 6.14 | 6.14 |
| 430.46 | 5.37 | 5.37 |
| 460.49 | 5.38 | 5.38 |
| 420.42 | 4.97 | 4.97 |
| 448.45 | 5.51 | 5.51 |
| 444.49 | 5.68 | 5.68 |
| 448.45 | 5.51 | 5.51 |
| 509.36 | 6.14 | 6.14 |
| 460.49 | 5.14 | 5.14 |
| 509.36 | 6.14 | 6.14 |
| 480.52 | 6.53 | 6.53 |
| 436.49 | 5.44 | 5.44 |
| 431.45 | 4.77 | 4.77 |
| 424.45 | 4.24 | 4.24 |
| 556.36 | 5.98 | 5.98 |
| 480.52 | 6.53 | 6.53 |
| 460.49 | 5.38 | 5.38 |
| 420.42 | 4.97 | 4.97 |
| 444.49 | 5.68 | 5.68 |
| 464.91 | 6.03 | 6.03 |
| 474.51 | 5.77 | 5.77 |
| 460.49 | 5.38 | 5.38 |
| 470.48 | 6.12 | 6.12 |