Basic Information
ID: ALA5164913
Type: Binding
Description: Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in IL-1beta secretion preincubated for 3 hrs with LPS and for 30 mins with compound prior to nigericin addition and measured after 30 mins by ELISA
Organism: Mus musculus
Strain: C57BL/6
Cell type: BMDM
Activity Charts
Bioactivity
Activity Types for Assay ALA5164913
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 193.16 | 1.66 | 1.66 |
| 364.44 | 0.38 | 0.38 |
| 456.50 | 5.77 | 5.77 |
| 448.45 | 5.51 | 5.51 |
| 509.36 | 6.14 | 6.14 |
| 430.46 | 5.37 | 5.37 |
| 480.52 | 6.53 | 6.53 |
| 436.49 | 5.44 | 5.44 |
| 420.42 | 4.97 | 4.97 |
| 460.49 | 5.38 | 5.38 |