Basic Information
ID: ALA5164919
Type: Binding
Description: Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in activated caspase 1(P20) level in cell lysates at 0.5 to 2 uM preincubated for 3 hrs with LPS and for 30 mins with compound prior to nigericin addition and measured after 30 mins by Western blot analysis
Organism: Mus musculus
Strain: C57BL/6
Cell type: BMDM
Subcellular Fraction: Lysates
Activity Charts
Bioactivity
Activity Types for Assay ALA5164919
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 420.42 | 4.97 | 4.97 |