Basic Information
ID: ALA5164927
Type: Binding
Description: Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated C57BL/6 mouse bone marrow-derived macrophages assessed as reduction in NEK7-NLRP3 protein-protein interaction at 2 to 4 uM preincubated for 3 hrs with LPS and for 30 mins with compound prior to nigericin addition and measured after 30 mins by immunoprecipitation method
Organism: Mus musculus
Strain: C57BL/6
Cell type: BMDM
Activity Charts
Bioactivity
Activity Types for Assay ALA5164927
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 420.42 | 4.97 | 4.97 |