Assay Report Card

Basic Information

ID: ALA5167929

Type: Functional

Description: In vivo inhibition of PRMT5 in human A-375 cells xenografted in BALB/c mouse assessed as reduction in H3R8me2s levels in tumor tissue at 75 mg/kg, po qd for 19 days measured after 3 weeks by Western blot analysis

Organism: Mus musculus

Strain: BALB/c

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
396.495.145.14