Basic Information
ID: ALA5217806
Type: Binding
Description: Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated with LPS for 3 hrs followed by compound addition for 30 mins and further stimulated with nigericin for 1.5 hrs by ELISA analysis
Organism: Homo sapiens
Cell type: PBMC
Activity Charts
Bioactivity
Activity Types for Assay ALA5217806
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 404.49 | 2.99 | 2.99 |
| 356.45 | 3.17 | 3.17 |
| 346.41 | 2.77 | 2.77 |
| 487.58 | 1.46 | 1.46 |
| 360.44 | 1.91 | 1.91 |
| 357.44 | 2.57 | 2.57 |
| 400.50 | 2.71 | 2.71 |
| 431.52 | 1.35 | 1.35 |
| 358.42 | 1.96 | 1.96 |
| 429.50 | 1.46 | 1.46 |
| 459.57 | 1.94 | 1.94 |
| 357.44 | 2.57 | 2.57 |
| 402.48 | 2.15 | 2.15 |
| 377.49 | 2.94 | 2.94 |
| 363.46 | 2.63 | 2.63 |
| 431.52 | 1.35 | 1.35 |
| 374.47 | 2.22 | 2.22 |
| 397.46 | 2.22 | 2.22 |
| 388.49 | 2.95 | 2.95 |
| 360.44 | 1.91 | 1.91 |
| 445.55 | 1.69 | 1.69 |
| 357.44 | 2.57 | 2.57 |
| 360.44 | 1.91 | 1.91 |
| 374.47 | 2.22 | 2.22 |