Basic Information
ID: ALA5225583
Type: Binding
Description: Inhibition of mPGES-1 activity in IL-1beta stimulated human A549 microsomal preparation using PGH2 as substrate assessed as inhibition of PGE2 synthesis by measuring residual activity at 10 uM preincubated for 15 mins followed by substrate addition and measured after 1 min by RP-HPLC analysis relative to control
Organism: Homo sapiens
Cell type: A549
Subcellular Fraction: Microsome
Activity Charts
Bioactivity
Activity Types for Assay ALA5225583
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 422.90 | 5.19 | 5.19 |
| 376.44 | 4.61 | 4.61 |
| 421.91 | 5.06 | 5.06 |
| 409.42 | 5.11 | 5.11 |
| 408.43 | 4.98 | 4.98 |
| 377.43 | 4.73 | 4.73 |
| 451.35 | 5.47 | 5.47 |
| 452.33 | 5.59 | 5.59 |
| 442.33 | 5.41 | 5.41 |