Basic Information
ID: ALA5225584
Type: Binding
Description: Inhibition of mPGES-1 activity in IL-1beta stimulated human A549 microsomal preparation using PGH2 as substrate assessed as inhibition of PGE2 synthesis preincubated for 15 mins followed by substrate addition and measured after 1 min by RP-HPLC analysis
Organism: Homo sapiens
Cell type: A549
Subcellular Fraction: Microsome
Activity Charts
Bioactivity
Activity Types for Assay ALA5225584
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 422.90 | 5.19 | 5.19 |
| 376.44 | 4.61 | 4.61 |
| 421.91 | 5.06 | 5.06 |
| 409.42 | 5.11 | 5.11 |
| 408.43 | 4.98 | 4.98 |
| 377.43 | 4.73 | 4.73 |
| 451.35 | 5.47 | 5.47 |
| 452.33 | 5.59 | 5.59 |
| 442.33 | 5.41 | 5.41 |