Basic Information
ID: ALA5226037
Type: Binding
Description: Inhibition of 6His-tagged SOS1 (unknown origin) mediated GST-tagged KRAS G12D activation preincubated for 15 mins followed by KRAS G12D addition and measured after 30 mins by HTRF assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5226037
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 462.47 | 4.89 | 4.89 |
| 487.53 | 4.55 | 4.55 |
| 488.51 | 3.83 | 3.83 |
| 502.54 | 4.31 | 4.31 |
| 516.57 | 4.70 | 4.70 |
| 420.40 | 3.06 | 3.06 |
| 378.36 | 2.68 | 2.68 |
| 420.52 | 2.81 | 2.81 |
| 502.54 | 4.14 | 4.14 |
| 489.50 | 4.13 | 4.13 |
| 474.49 | 3.82 | 3.82 |
| 503.53 | 3.45 | 3.45 |
| 473.50 | 4.25 | 4.25 |
| 444.54 | 3.41 | 3.41 |
| 446.48 | 3.57 | 3.57 |
| 440.43 | 4.16 | 4.16 |
| 474.49 | 3.27 | 3.27 |
| 571.65 | 4.15 | 4.15 |
| 439.44 | 4.77 | 4.77 |
| 485.54 | 3.31 | 3.31 |
| 446.48 | 4.46 | 4.46 |
| 363.34 | 3.10 | 3.10 |
| 445.44 | 3.82 | 3.82 |
| 460.50 | 4.85 | 4.85 |
| 489.50 | 2.77 | 2.77 |