Basic Information
ID: ALA5226254
Type: Binding
Description: Allosteric inhibition of IRS1 peptide-activated human recombinant SHP2 (Met1 to Leu525) expressed in Escherichia coli assessed as inhibition of dephosphorylation of 6,8-difluoro-4-methylumbelliferyl phosphate using DiFMUP as substrate preincubated with enzyme for 30 mins followed by substrate addition and measured after 30 mins by DiFMUP assay
Format: BAO_0000019
Organism: Homo sapiens
Target: Protein-tyrosine phosphatase 2C(ALA3864)
Document: ALA5223191
Allosteric inhibition of IRS1 peptide-activated human recombinant SHP2 (Met1 to Leu525) expressed in Escherichia coli assessed as inhibition of dephosphorylation of 6,8-difluoro-4-methylumbelliferyl phosphate using DiFMUP as substrate preincubated with enzyme for 30 mins followed by substrate addition and measured after 30 mins by DiFMUP assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5226254
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 352.27 | 3.35 | 3.35 |
| 384.43 | 2.94 | 2.94 |
| 409.44 | 3.24 | 3.24 |
| 408.45 | 3.84 | 3.84 |
| 449.51 | 4.02 | 4.02 |
| 393.28 | 3.77 | 3.77 |
| 395.41 | 2.85 | 2.85 |
| 479.01 | 3.98 | 3.98 |
| 409.44 | 3.24 | 3.24 |
| 497.55 | 4.76 | 4.76 |
| 409.44 | 3.11 | 3.11 |
| 493.04 | 4.44 | 4.44 |
| 426.49 | 3.97 | 3.97 |
| 423.37 | 4.44 | 4.44 |
| 423.47 | 3.25 | 3.25 |
| 407.47 | 4.45 | 4.45 |
| 464.00 | 4.40 | 4.40 |
| 426.49 | 3.97 | 3.97 |
| 409.35 | 4.13 | 4.13 |
| 465.51 | 3.25 | 3.25 |
| 377.28 | 3.64 | 3.64 |
| 423.47 | 3.25 | 3.25 |
| 395.41 | 2.85 | 2.85 |