Basic Information
ID: ALA5229861
Type: Binding
Description: Inhibition of 6his/TEV-fused GST tagged SARS-CoV-2 MPro (1 to 306 residues) expressed in Escherichia coli RIL cells using 5-FAM-AVLQSGFR-Lys-(Dabcyl)-K-amide as substrate assessed as substrate cleavage preincubated for 30 mins followed by substrate addition and measured every 30 sec for 60 cycles by FRET based assay
Format: BAO_0000219
Organism: Severe acute respiratory syndrome coronavirus 2
Target: Replicase polyprotein 1ab(ALA4523582)
Document: ALA5226382
Inhibition of 6his/TEV-fused GST tagged SARS-CoV-2 MPro (1 to 306 residues) expressed in Escherichia coli RIL cells using 5-FAM-AVLQSGFR-Lys-(Dabcyl)-K-amide as substrate assessed as substrate cleavage preincubated for 30 mins followed by substrate addition and measured every 30 sec for 60 cycles by FRET based assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5229861
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 270.24 | 2.58 | 2.58 |
| 401.57 | 1.50 | 1.50 |
| 708.72 | 6.25 | 6.25 |
| 626.61 | 5.75 | 5.75 |
| 420.46 | 5.27 | 5.27 |
| 708.72 | 6.25 | 6.25 |
| 420.46 | 5.27 | 5.27 |
| 482.58 | 2.89 | 2.89 |
| 708.72 | 6.25 | 6.25 |
| 694.73 | 7.48 | 7.48 |