Basic Information
ID: ALA5238191
Type: Binding
Description: Inhibition of SOS1/KRAS G13D mutant protein-protein interaction in human DLD-1 cells assessed as ERK1/2 phosphorylation measured after 1 hr by homogeneous time-resolved fluorescence (HTRF) method
Organism: Homo sapiens
Cell type: DLD-1
Activity Charts
Bioactivity
Activity Types for Assay ALA5238191
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 462.47 | 4.89 | 4.89 |
| 536.56 | 4.90 | 4.90 |
| 514.55 | 4.80 | 4.80 |
| 543.59 | 4.54 | 4.54 |
| 529.54 | 5.10 | 5.10 |
| 404.39 | 4.48 | 4.48 |
| 527.55 | 4.24 | 4.24 |
| 569.63 | 4.44 | 4.44 |
| 459.47 | 4.31 | 4.31 |
| 515.54 | 4.24 | 4.24 |
| 501.51 | 4.84 | 4.84 |
| 537.55 | 4.63 | 4.63 |
| 528.58 | 4.16 | 4.16 |
| 541.57 | 4.63 | 4.63 |
| 514.55 | 3.99 | 3.99 |
| 554.62 | 4.69 | 4.69 |
| 445.45 | 4.46 | 4.46 |
| 526.56 | 4.94 | 4.94 |
| 555.60 | 5.02 | 5.02 |
| 529.54 | 4.96 | 4.96 |
| 514.55 | 4.75 | 4.75 |
| 541.57 | 4.63 | 4.63 |
| 542.61 | 4.77 | 4.77 |
| 529.54 | 4.96 | 4.96 |
| 556.59 | 4.52 | 4.52 |
| 511.55 | 5.01 | 5.01 |
| 547.53 | 5.25 | 5.25 |
| 485.51 | 4.62 | 4.62 |
| 527.55 | 4.39 | 4.39 |
| 499.54 | 4.47 | 4.47 |
| 485.55 | 5.48 | 5.48 |
| 501.55 | 4.72 | 4.72 |
| 512.58 | 4.39 | 4.39 |
| 500.53 | 4.41 | 4.41 |
| 539.54 | 5.20 | 5.20 |
| 525.58 | 5.40 | 5.40 |
| 551.57 | 4.64 | 4.64 |
| 568.64 | 4.94 | 4.94 |
| 527.59 | 5.64 | 5.64 |
| 485.51 | 4.62 | 4.62 |
| 500.53 | 4.14 | 4.14 |
| 500.53 | 4.14 | 4.14 |
| 521.57 | 4.03 | 4.03 |
| 529.56 | 4.63 | 4.63 |
| 515.54 | 3.76 | 3.76 |
| 457.50 | 4.70 | 4.70 |
| 527.59 | 5.25 | 5.25 |
| 555.60 | 5.02 | 5.02 |
| 472.52 | 4.23 | 4.23 |
| 485.51 | 4.62 | 4.62 |
| 567.66 | 6.28 | 6.28 |