Assay Report Card

Basic Information

ID: ALA5239759

Type: Binding

Description: Agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as transcriptional activation at 30 uM incubated for 24 hrs by luminescence based analysis

Organism: Homo sapiens

Cell type: HepG2

Activity Charts

Bioactivity

Activity Types for Assay ALA5239759

Activity

Total(64)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
438.53	4.54	4.54
466.58	5.32	5.32
520.55	6.21	6.21
537.66	4.24	4.24
536.68	3.77	3.77
481.60	4.08	4.08
523.63	3.85	3.85
471.00	5.97	5.97
410.47	3.85	3.85
504.55	6.33	6.33
454.55	5.45	5.45
419.49	4.01	4.01
423.47	2.68	2.68
424.50	4.15	4.15
394.48	4.14	4.14
423.52	4.18	4.18
465.60	5.35	5.35
410.47	3.85	3.85
450.58	5.62	5.62
482.58	4.29	4.29
366.42	3.41	3.41
421.50	3.84	3.84
466.58	5.32	5.32
450.58	5.44	5.44
407.47	3.45	3.45
485.03	6.35	6.35
462.51	3.32	3.32
464.61	6.01	6.01
394.48	4.14	4.14
494.64	6.10	6.10
473.37	4.91	4.91
465.60	5.35	5.35
428.45	2.43	2.43
381.44	2.91	2.91
520.44
403.44	3.64	3.64
424.50	4.15	4.15
436.52	2.60	2.60
464.61	6.01	6.01
395.46	3.54	3.54
480.61	5.57	5.57
470.57	5.81	5.81
436.56	5.31	5.31
480.61	5.71	5.71
485.03	6.35	6.35
495.62	4.47	4.47
480.61	5.71	5.71
437.54	4.71	4.71
480.61	5.71	5.71
380.45	3.97	3.97
515.45	6.08	6.08
522.69	6.88	6.88
437.54	4.21	4.21
480.61	5.57	5.57
409.49	3.72	3.72
407.52	4.70	4.70
480.61	5.71	5.71
521.71	6.55	6.55
449.51	4.05	4.05
485.03	6.35	6.35
515.45	6.08	6.08
471.00	5.97	5.97
452.56	4.93	4.93
430.53	3.69	3.69