Basic Information
ID: ALA5239760
Type: Binding
Description: Inverse agonist activity at human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as inhibition in receptor basal activity at 30 uM incubated for 24 hrs by luminescence based analysis
Organism: Homo sapiens
Cell type: HepG2
Activity Charts
Bioactivity
Activity Types for Assay ALA5239760
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 822.95 | 4.34 | 4.34 |
| 520.55 | 6.21 | 6.21 |
| 406.53 | 5.30 | 5.30 |
| 509.61 | 5.49 | 5.49 |
| 409.49 | 3.72 | 3.72 |
| 471.00 | 5.97 | 5.97 |
| 410.47 | 3.85 | 3.85 |
| 466.58 | 5.32 | 5.32 |
| 504.55 | 6.33 | 6.33 |
| 407.52 | 4.70 | 4.70 |
| 352.39 | 3.15 | 3.15 |
| 454.55 | 5.45 | 5.45 |
| 423.47 | 2.68 | 2.68 |
| 409.49 | 3.72 | 3.72 |
| 465.60 | 5.35 | 5.35 |
| 464.61 | 6.01 | 6.01 |
| 450.58 | 5.62 | 5.62 |
| 366.42 | 3.41 | 3.41 |
| 451.53 | 4.10 | 4.10 |
| 466.58 | 5.32 | 5.32 |
| 437.54 | 4.21 | 4.21 |
| 485.03 | 6.35 | 6.35 |
| 464.61 | 6.01 | 6.01 |
| 394.48 | 4.14 | 4.14 |
| 338.37 | 2.85 | 2.85 |
| 466.58 | 5.32 | 5.32 |
| 454.55 | 5.45 | 5.45 |
| 381.44 | 2.91 | 2.91 |
| 423.52 | 4.18 | 4.18 |
| 403.44 | 3.64 | 3.64 |
| 424.50 | 4.15 | 4.15 |
| 436.56 | 5.31 | 5.31 |
| 394.48 | 4.14 | 4.14 |
| 436.52 | 2.60 | 2.60 |
| 464.61 | 6.01 | 6.01 |
| 466.58 | 5.32 | 5.32 |
| 436.56 | 5.31 | 5.31 |
| 451.53 | 4.10 | 4.10 |
| 485.03 | 6.35 | 6.35 |
| 450.58 | 5.62 | 5.62 |
| 437.54 | 4.71 | 4.71 |
| 466.58 | 5.32 | 5.32 |
| 450.54 | 5.03 | 5.03 |
| 515.45 | 6.08 | 6.08 |
| 407.52 | 4.70 | 4.70 |
| 449.51 | 4.05 | 4.05 |
| 485.03 | 6.35 | 6.35 |
| 471.00 | 5.97 | 5.97 |
| 436.56 | 5.31 | 5.31 |