Basic Information
ID: ALA5240999
Type: Binding
Description: Chaperone activity at GCase N370S GBA mutant in patient derived fibroblast cell using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate assessed as substrate cleavage by measuring maximal response incubated for 5 days by fluorescence based assay relative to isofagomine
Organism: Homo sapiens
Cell type: Fibroblast
Activity Charts
Bioactivity
Activity Types for Assay ALA5240999
Emax
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 338.46 | 3.18 | 3.18 |
| 393.54 | 3.44 | 3.44 |
| 352.44 | 1.74 | 1.74 |
| 393.49 | 2.38 | 2.38 |
| 353.43 | 1.14 | 1.14 |
| 407.56 | 3.65 | 3.65 |
| 351.45 | 2.35 | 2.35 |
| 351.45 | 2.27 | 2.27 |
| 365.48 | 2.66 | 2.66 |
| 289.38 | 1.05 | 1.05 |
| 339.44 | 2.12 | 2.12 |
| 385.90 | 3.00 | 3.00 |
| 365.48 | 2.28 | 2.28 |
| 381.48 | 1.89 | 1.89 |
| 385.90 | 3.00 | 3.00 |
| 365.48 | 2.66 | 2.66 |
| 433.60 | 3.83 | 3.83 |
| 379.51 | 3.05 | 3.05 |
| 377.49 | 2.66 | 2.66 |
| 401.46 | 2.90 | 2.90 |
| 401.51 | 3.50 | 3.50 |
| 435.57 | 3.37 | 3.37 |
| 391.52 | 2.90 | 2.90 |
| 391.52 | 2.84 | 2.84 |
| 407.52 | 2.42 | 2.42 |
| 447.63 | 4.22 | 4.22 |
| 369.44 | 2.49 | 2.49 |
| 419.45 | 3.37 | 3.37 |
| 357.50 | 2.61 | 2.61 |
| 365.48 | 2.66 | 2.66 |
| 365.48 | 2.66 | 2.66 |
| 381.48 | 1.84 | 1.84 |
| 379.51 | 3.05 | 3.05 |
| 379.51 | 2.96 | 2.96 |
| 427.55 | 4.01 | 4.01 |
| 351.45 | 2.35 | 2.35 |