Basic Information
ID: ALA5242984
Type: Binding
Description: Inhibition of human recombinant N-terminal His6-tagged eIF4A expressed in Escherichia coli BL21 CodonPlus cells using ATP and yeast RNA as substrate preincubated with enzyme for 20 mins followed by susbtrate addition and measured after 4 hrs by Malachite green ATPase assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5242984
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 455.43 | 7.10 | 7.10 |
| 413.52 | 7.33 | 7.33 |
| 450.33 | 6.97 | 6.97 |
| 478.39 | 7.44 | 7.44 |
| 497.33 | 6.81 | 6.81 |
| 405.88 | 6.86 | 6.86 |
| 427.46 | 5.91 | 5.91 |
| 436.42 | 6.44 | 6.44 |
| 450.33 | 6.97 | 6.97 |
| 450.33 | 6.97 | 6.97 |
| 405.88 | 6.86 | 6.86 |
| 418.41 | 5.56 | 5.56 |
| 439.43 | 7.22 | 7.22 |
| 426.47 | 6.52 | 6.52 |
| 427.46 | 5.91 | 5.91 |
| 399.49 | 6.77 | 6.77 |
| 430.46 | 6.50 | 6.50 |
| 427.46 | 5.91 | 5.91 |
| 418.41 | 5.56 | 5.56 |
| 444.49 | 6.59 | 6.59 |
| 404.33 | 4.50 | 4.50 |
| 405.88 | 6.86 | 6.86 |
| 386.45 | 5.78 | 5.78 |
| 439.43 | 7.22 | 7.22 |
| 385.46 | 6.51 | 6.51 |
| 426.47 | 6.52 | 6.52 |
| 410.39 | 5.92 | 5.92 |
| 416.43 | 6.11 | 6.11 |
| 385.46 | 6.51 | 6.51 |
| 440.33 | 7.51 | 7.51 |
| 405.88 | 6.86 | 6.86 |
| 399.49 | 6.82 | 6.82 |
| 418.41 | 5.56 | 5.56 |
| 360.33 | 4.77 | 4.77 |
| 407.42 | 6.48 | 6.48 |
| 389.43 | 6.34 | 6.34 |
| 401.46 | 6.21 | 6.21 |
| 452.42 | 6.56 | 6.56 |
| 375.34 | 4.35 | 4.35 |
| 475.46 | 6.12 | 6.12 |
| 432.50 | 6.58 | 6.58 |
| 452.42 | 6.56 | 6.56 |
| 447.53 | 7.87 | 7.87 |
| 452.42 | 6.56 | 6.56 |
| 389.43 | 6.34 | 6.34 |
| 436.42 | 6.44 | 6.44 |
| 428.49 | 6.16 | 6.16 |
| 375.34 | 4.35 | 4.35 |
| 402.41 | 5.72 | 5.72 |
| 371.44 | 6.20 | 6.20 |
| 416.43 | 6.11 | 6.11 |
| 475.46 | 6.12 | 6.12 |
| 415.45 | 5.85 | 5.85 |
| 407.42 | 6.48 | 6.48 |