Basic Information
ID: ALA5244410
Type: ADME
Description: Time-dependent inhibition of CYP3A4 in human liver microsomes at 5 uM using midazolam as substrate preincubated for 0 to 30 mins followed by midazolam addition and measured after 20 mins by LC-MS/MS analysis relative to control
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Target: Cytochrome P450 3A4(ALA340)
Document: ALA5244205
Time-dependent inhibition of CYP3A4 in human liver microsomes at 5 uM using midazolam as substrate preincubated for 0 to 30 mins followed by midazolam addition and measured after 20 mins by LC-MS/MS analysis relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5244410
TDI
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 312.38 | 1.54 | 1.54 |
| 338.37 | 1.53 | 1.53 |
| 346.39 | 2.71 | 2.71 |
| 384.44 | 1.54 | 1.54 |
| 381.40 | 0.30 | 0.30 |
| 335.41 | 3.15 | 3.15 |
| 346.39 | 2.71 | 2.71 |
| 321.38 | 2.84 | 2.84 |
| 373.42 | 2.56 | 2.56 |
| 321.38 | 2.84 | 2.84 |
| 382.47 | 2.69 | 2.69 |
| 335.41 | 3.15 | 3.15 |
| 366.43 | 2.17 | 2.17 |