Basic Information
ID: ALA5248849
Type: Binding
Description: Inhibition of 6His tagged Mant-GDP loaded human KRAS G12C mutant (1 to 169 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of SOS1-mediated nucleotide exchange at 10 uM preincubated with compound for 1 hrs followed by addition of GTP and SOS1 protein and measured every 90 sec for 2 hrs by fluorescence based assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5248849
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 330.22 | 2.69 | 2.69 |
| 398.21 | 3.71 | 3.71 |
| 410.28 | 4.06 | 4.06 |