Basic Information
ID: ALA5248860
Type: Functional
Description: Invivo inhibition of KRAS signaling in BALB/C mouse xenografted with human NCI-H358 cells harboring KRAS G12C mutant assessed as decrease in ERK phosphorylation in tumor at 10 to 15 mg/kg, ip administered for 21 days by IHC staining based analysis
Organism: Mus musculus
Strain: BALB/C
Activity Charts
Bioactivity
Activity Types for Assay ALA5248860
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 410.28 | 4.06 | 4.06 |