Basic Information
ID: ALA5251706
Type: Binding
Description: Inhibition of C-terminal his tagged mCherry-DYRK1A (26 to 490 residues) in HEK293T cells assessed as restoration of DYRK1A overexpression mediated calcinurin/NFAT pathway inhibition by measuring ionomycin-stimulated nuclear translocation and accumulation of EGFP-NFAT at 5 uM incubated for 3 hrs followed by ionomycin stimulation for 1 hr by Hoechst 33258 staining based fluorescence microscopic analysis
Organism: Homo sapiens
Cell type: HEK293T
Activity Charts
Bioactivity
Activity Types for Assay ALA5251706
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 212.25 | 3.03 | 3.03 |
| 349.78 | 4.88 | 4.88 |