Basic Information
ID: ALA5251813
Type: Binding
Description: PROTAC activity at VHL/SOS1 in human ASPC1 cells harboring KRAS G12D mutant assessed as induction of SOS1 degradation at 1 uM preincubated with (R)-1-(4-(4-((1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)amino)-7-methoxy-2-methylquinazolin-6-yl)piperidin-1-yl)ethanone for 4 hrs followed by compound treatment and measured after 24 hrs by immunoblot analysis
Organism: Homo sapiens
Cell type: ASPC1
Activity Charts
Bioactivity
Activity Types for Assay ALA5251813
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 1028.26 |