Basic Information
ID: ALA5254744
Type: Binding
Description: Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha6-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as maximal efficacy at -80 mV holding potential at 30 nM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay
Organism: Rattus norvegicus
Cell type: Oocyte
Activity Charts
Bioactivity
Activity Types for Assay ALA5254744
Efficacy
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 291.31 | 2.83 | 2.83 |
| 321.34 | 2.84 | 2.84 |
| 370.21 | 3.59 | 3.59 |
| 309.30 | 2.97 | 2.97 |
| 305.34 | 3.14 | 3.14 |
| 325.75 | 3.48 | 3.48 |
| 319.36 | 3.39 | 3.39 |
| 359.31 | 3.85 | 3.85 |
| 315.33 | 2.81 | 2.81 |
| 333.35 | 3.03 | 3.03 |